[Phys-seminars] 2017-05-24 Nanotechnology Seminar -Ratnesh Lal

Ilse Katz Nanotechnology Institute nano at bgu.ac.il
Wed May 17 11:59:27 IDT 2017


Nanotechnology Seminar, Wednesday May 24th, 12:00, 2017
IKI Auditorium, Building 51, room 015

Remotely switchable Smart nano-carriers for On-Demand and Targeted Personalized Medicine

Ratnesh Lal

Center for Excellence in Nanomedicine and Engineering University of California San Diego


Abstract:
Nanomaterial-based nano-carriers of therapeutics, including drugs, small biologics and siRNAs, as well as imaging contrast molecules for high resolution diagnosis, jointly termed as theranostics (therapy and diagnosis) have attracted much attention for human health management. Existing techniques however are inefficient in deep tissue delivery of theranostics and lack on-demand controlled release of imaging contrast molecules or drugs and other therapeutics. We have designed patented multi-functional nano-carriers, termed Janus nanobowls and nano-golf balls containing nano magnetic particles for magnetically or acoustically targeted delivery and remote on-off release of the cargos. I will discuss these novel nanocapsules for controlling the pharmaco-distribution of therapeutics and imaging contrast molecules in cancer, their transfer across the blood-brain-barrier to brain as well as other organs. For cancer delivery, nanocapsules contain defined anticancer drugs, imaging contrast molecules and magnetic nanoparticles to provide a powerful magnetic vector under moderate gradient magnetic fields. These nanocapsules penetrate into the interior of tumors and allow a controlled on-off switchable release of the drug cargo via remote RF field. Similar carriers are modified for their transport across the blood-brain barrier (BBB), a major obstacle to delivering imaging/therapeutic agents. Using patented nucleic acid selective zippers and tweezer as the gate/cap of the carriers, these nanobowls and nano golf balls can be used for disease diagnosis and treatment, including genetic and viral abnormalities, infections, degenerative and rare diseases.

Biography: Bio data: Biographical Sketch: Prof. Lal received his MS/M Phil in Physics/Biophysics from JNU, India, Ph.D. in Neurobiology from UAB, and postdoctoral training at Caltech. He held faculty positions at the University of Chicago and UCSB and then the Director of the Center of Nanomedicine and professorships in Medicine, Biophysical Sciences and Cell Physiology at the University of Chicago. Currently, he holds joint professorships in Bioengineering, Mechanical Engineering, and Materials Science, and is the co-Director for the Center for Excellence in Nanomedicine and Engineering at UCSD. He is a Fellow of AAAS (the American Association for Advancement of Science) and a Fellow of the American Institute of Medical and Biological Engineering (AIMBE). He was the UTS Invited Professor in Sydney for their Bionanotechnology initiative and a New Zealand Government International Science Scholar. He is a Visiting Professor at the Chinese Academy of Sciences, Institute for Applied Physics, Shanghai. He is an Associate Editor of the Journal Nanomedicine: Nanotechnology, Biology, Medicine. He is the Chairman of American Nanoslutions, LLC, Vessel ANI, Inc and is on advisory board of RC Nano LLC and Be Green Packaging LLC. He has presented many international keynote lectures and is featured in many popular magazines and news media, including Time and Smithsonian. He holds several patents based upon AFM cantilever arrays, microfluidics, optoelectronics and nanotubes for medical diagnostics, Nano biosensors and in-vivo medical Nano devices, nanoscale fluid behavior and new TIRF, FRET and related optical microscopy


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